A substance that is broken down (metabolized) from serotonin. A high level of 5-HIAA in a 24-hour urine test sample can be used to confirm whether a person’s symptoms, such as flushing of the skin (particularly the face) and diarrhea, are due to carcinoid syndrome. 5-HIAA also can be done by blood known as the 5-HIAA Serum.
A rare and aggressive subtype of goblet cell carcinoid, a distinct tumor of the appendix characterized by both neuroendocrine and glandular differentiation. Patients often present with chronic abdominal pain or symptoms of acute appendicitis.
Also known as Neuroendocrine cancer of the stomach. Currently considered very rare. There are 3 Types of G-nets which are classified upon their location within the stomach and their type of association with other syndromes or infections. Surveillance and treatment may vary according to Type. Knowing the Gastric Nets Type is equally as important as knowing the Stage and Grade of a G-Net.
Type 1 is often associated with H.pylori infection and/or auto-immune gastritis. It is the most common type of Gastric nets, usually very small and presenting in multiple. It rarely is an aggressive disease.
Type 2 is often found in conjunction with MEN1 or Zollinger Ellison syndrome. These tumors are also typically very small with multiple presentation. Slightly higher chance of metastasis than Type 1.
Type 3 may be well or poorly differentiated tumors, considerably larger than Types 1 and 2. Type 3 is the most aggressive and is more likely to grow in size and/or metastize.
A NET that most often starts in the gastrointestinal tract. GEP-NETs are sometimes called carcinoid tumors or islet cell tumors.
A method of assigning degree of tracer uptake. Most frequently used with an Octreotide Scan. Occasionally it is used as an indication of a patient’s acceptability for PRRT Therapy. The Scores range from 0 (not acceptable) to 4. A score greater than 2 indicates consideration for PRRT.
A rare tumor which contains both Neuroendocrine and non Neuroendocrine characteristics (frequently adenocarcinoma/adenocarcinoma). Most typically found in the GEP-Net tract.